GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2275426 | 1 | rs12405451 | chr1:46384326 | MUTYH | chr1:45794915-45806142:- | 0.12 | 4.86 | 1.33E-6 | Body mass index |
| BRCA | cis | rs17401966 | 1 | rs12407992 | chr1:10311983 | PGD | chr1:10459085-10480200:+ | 0.14 | 4.1 | 4.41E-5 | Hepatocellular carcinoma |
| BRCA | cis | rs2275426 | 1 | rs12409773 | chr1:46358831 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.79 | 2.88E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12409773 | chr1:46358831 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.48 | 0.000529 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12409773 | chr1:46358831 | MUTYH | chr1:45794915-45806142:- | 0.13 | 4.97 | 7.79E-7 | Body mass index |
| BRCA | cis | rs3931020 | 1 | rs12410060 | chr1:75245848 | CRYZ | chr1:75171175-75199092:- | -0.38 | -10.24 | 1.58E-23 | Resistin levels |
| BRCA | cis | rs2275426 | 1 | rs12410071 | chr1:46358886 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.79 | 2.88E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12410071 | chr1:46358886 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.48 | 0.000529 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12410071 | chr1:46358886 | MUTYH | chr1:45794915-45806142:- | 0.13 | 4.97 | 7.79E-7 | Body mass index |
| BRCA | cis | rs7523273 | 1 | rs12410786 | chr1:207976205 | C4BPA | chr1:207277511-207318308:+ | -0.12 | -3.65 | 0.00027 | Schizophrenia |
| BRCA | cis | rs2275426 | 1 | rs12411269 | chr1:46271052 | CCDC163P | chr1:45960581-45965646:- | -0.41 | -12.06 | 1.82E-31 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12411269 | chr1:46271052 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.46 | 0.000568 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12411269 | chr1:46271052 | MUTYH | chr1:45794915-45806142:- | 0.12 | 4.86 | 1.36E-6 | Body mass index |
| BRCA | cis | rs9527 | 1 | rs12416687 | chr10:104629011 | AS3MT | chr10:104613967-104661653:+ | -0.23 | -5.73 | 1.29E-8 | Arsenic metabolism |
| BRCA | cis | rs9527 | 1 | rs12416687 | chr10:104629011 | C10orf32 | chr10:104613967-104624718:+ | -0.37 | -12.54 | 9.4E-34 | Arsenic metabolism |